NASDAQ$ABOS
Acumen Pharmaceuticals Inc · Q2 2025 earnings
Q2 2025 earnings · · Before market open · Investor relations
Briefing
Acumen Pharmaceuticals Inc reported a net loss of $41.0 million for Q2 2025 driven by increased R&D spending on its Phase 2 ALTITUDE-AD trial.
The company continued advancing sabirnetug in clinical development with no product revenue. Operating expenses rose sharply to $41.8 million, primarily from manufacturing, materials, and CRO costs for the ALTITUDE-AD trial. Cash, cash equivalents, and marketable securities totaled $166.2 million, providing runway into early 2027.
- Q2 2025 net loss widened to $41.0 million from $20.5 million in Q2 2024 due to higher R&D expenses of $37.1 million.
- ALTITUDE-AD Phase 2 trial enrollment completed in March 2025; top-line results expected late 2026.
- Cash and marketable securities of $166.2 million support operations into early 2027.
- Entered collaboration with JCR Pharmaceuticals in July 2025 for EBD therapy development.
Headline financials
Revenue & EPS history
Acumen · Revenue · Quarterly
$0
Forward guidance
Company expects top-line results from ALTITUDE-AD in late 2026 and continues development of subcutaneous and EBD formulations.
Tailwinds
- Completed ALTITUDE-AD enrollment ahead of schedule
- Positive Phase 1 subcutaneous data supporting further development
- New JCR collaboration expands pipeline options
Headwinds
- Increased cash burn from clinical activities
- No near-term revenue expected
Historical earnings impact
How earnings announcements have historically affected this stock's price.
Avg. return before/after earnings
Based on 17 quarterly earnings reports
+0.6%
Avg return
Earnings day
-3.3%
Avg return
5 days after
-6.4%
Avg return
30 days after
42%
8 / 19 earnings
Positive
+35.9%
Q1 2023
Best reaction
-21.4%
Q3 2024
Worst reaction
| Quarter | Report date | Reaction (Day 0) | +5 days | +30 days |
|---|---|---|---|---|
| Q2 2025 | — | — | — | |
| Q4 2025 | -2.3% | -9.8% | — | |
| Q1 2026 | -3.5% | -11.7% | -7.8% | |
| Q3 2025 | -1.5% | -19.8% | +8.6% | |
| Q1 2025 | +0.0% | +1.9% | +8.6% | |
| Q4 2024 | +6.0% | -7.3% | -6.9% | |
| Q3 2024 | -21.4% | -25.5% | -35.7% | |
| Q2 2024 | -1.6% | +0.4% | -4.3% | |
| Q1 2024 | +13.1% | +8.6% | -21.4% | |
| Q4 2023 | -3.5% | +8.0% | -20.6% | |
| Q3 2023 | +12.1% | +20.0% | +53.2% | |
| Q2 2023 | -3.1% | +2.0% | -19.9% | |
| Q1 2023 | +35.9% | +15.5% | +0.4% | |
| Q4 2022 | +2.3% | +3.6% | -4.1% | |
| Q3 2022 | -5.1% | -10.6% | -15.3% | |
| Q2 2022 | +4.6% | -11.5% | +9.4% | |
| Q1 2022 | +9.6% | +4.5% | +7.8% | |
| Q4 2021 | -14.8% | -22.0% | -22.2% | |
| Q3 2021 | -17.1% | -23.9% | -46.7% | |
| Q2 2021 | +1.6% | +13.9% | +1.1% | |
| Q1 2021 | — | — | — | |
| Q4 2020 | — | — | — | |
| Q3 2020 | — | — | — | |
| Q2 2020 | — | — | — | |
| Q1 2020 | — | — | — |
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